The Secretariat accepts students on weekdays from 12:00 - 13:30

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Study Guide 2019-20

Fousteris Manolis
Tel. : (+30) 2610 962391 Office
         (+30) 2610 962392 Lab / Postgraduate Students
Fax.: (+30) 2610 969182

E-mailThis e-mail address is being protected from spambots. You need JavaScript enabled to view it  

Current Position
Assistant Professor of Medicinal Chemistry, Department of Pharmacy, University of Patras, Greece.

Education
2000: Diploma in Pharmacy, University of Patras, Greece
2002: MSc in Medicinal Chemistry, University of Patras, Greece
2005: PhD in Medicinal Chemistry, University of Patras, Greece

Academic Appointments:
03/200606/2007: Teaching Assistant (Part-time Lecturer), Department of Pharmacy, University of Patras, Greece.
01/200909/2013: Lecturer in Medicinal Chemistry, Department of Pharmacy, University of Patras, Greece.
09/2013today): Assistant Professor of Medicinal Chemistry, Department of Pharmacy, University of Patras, Greece.

Research Career
10/2005 – 01/2006: Postdoctoral Researcher, CNRS - Université de Reims Champagne-Ardenne, Unité Mixte de Recherche No 6519-Réactions Sélectives et Applications, “Catalyse” Group.
10/2006 – 11/2007: Postdoctoral Researcher, Laboratory of Medicinal Chemistry, Department of Pharmacy, University of Patras, Greece.
12/2007 – 01/2009: Postdoctoral Researcher, Institute of Organic Chemistry, Department of Chemistry and Mineralogy, University of Leipzig, Germany.

Research Interests

  • Design, synthesis and biological evaluation of new steroidal alkylating agents
  • Discovery of novel small molecules as protein kinase inhibitors
  • Design and synthesis of new heterocyles as soluble guanylate cyclase (sGC) modulators
  • Design and synthesis of new steroids with potential anticancer activity
  • Design and synthesis of new C-nor-D-homo steroids as potential inhibitors of Hedgehog signaling pathway
  • Design and synthesis of new artemisinin-derived hybrid molecules with antimalarial and anticancer properties

Participation in Recent Research Projects

  • Research Grant “Κ. Κaratheodori (C.109)”, Research Committee, University of Patras, Greece.
    “Design, Synthesis and Biological Evaluation of Novel Pyrrolo- Indolo-azepinone Derivatives as Potential Inhibitors of the Cyclin Dependent Kinase 1 (CDK1)”. Duration time: 2010-2013.
    Research Coordinator.
  • Hrakleitos II, Ministry of Education-Hellenic Republic, European Union-FP7
    “Design, Synthesis and Biological Evaluation of New Indole Derivatives, Analogues of Natural Products as Potential Protein Kinase Inhibitors”. Duration time: 2011-2014.
    Research Coordinator: Associate Prof. Sotiris Nikolaropoulos. Research Scientist.
  • Hellenic Research Foundation for Research and Innovation (HFRI) Research Projects to support Post-Doctoral Researchers, General Secretariat for Research and Technology – Hellenic Republic,  HFRI
    “Enlightening the Conformational Changes of HNOX domain of soluble guanylate cyclase (sGC) by discrimination of diatomic gases”. Duration time: 2018-2021
    Research Coordinator: Dr. Aikaterini Zompra. Research Scientist - PhD Supervisor (D.-P. Kintos)

Publications
Papers in peer-reviewed international journals: 36
Abstracts in proceedings of international conferences: 28
Abstracts in proceedings of national conferences: 60

Professional Affiliations

  • Hellenic Society of Medicinal Chemistry

Teaching Activities

Undergraduate Courses

Undergraduate Program, Department of Pharmacy, University of Patras

  • Synthetic Organic Chemistry (PHA-Β12-NEW-3rd Semester)
  • Medicinal Chemistry I (PHA-C25-NEW -6th Semester)

Postgraduate Courses

Postgraduate Program in “Drug Discovery and Development”, Department of Pharmacy, University of Patras

  • Design and Discovery of New Bioactive Compounds (DPHA_1)
  • Modern Methods in Drug Synthesis (DPHA_Α02)
  • Biomolecular NMR and Protein Architecture (DPHA_Α03)

Interdepartmental Program of Postgraduate Studies “Informatics for Life Sciences”, Departments of Medicine, Biology, Pharmacy, Physics and Computer Engineering & Informatics, University of Patras

  • Basic Principles of Pathophysiology and Therapeutics (LSI102)

Selected Publications

  1. Roumana, A.; Yektaoğlu, A.; Pliatsika, D.; Bantzi, M.; Nikolaropoulos, S. S.; Giannis, A.*; Fousteris, M. A.* New Spiro-Lactam C-nor-D-homo Steroids. European Journal of Organic Chemistry 2018, 30, 4147-4160.
  2. Lampropoulou, E.; Logoviti, I.; Koutsioumpa, M.;, Hatziapostolou, M.;, Polytarchou, C.; Skandalis, S. S.; Hellman, U.; Fousteris, M.; Nikolaropoulos, S.; Choleva, E.; Lamprou, M.; Skoura, A.; Megalooikonomou, V.; Papadimitriou, E. Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration. Scientific Reports 2018, 8, 5893.
  3. Letis, A. S.; Seo E. J.; Nikolaropoulos S. S; Efferth, T; Giannis, A*; Fousteris M. A.* Synthesis and cytotoxic activity of new artemisinin hybrid molecules against human leukemia cells. Bioorganic Medicinal Chemistry 2017, 25, 3357-3367.
  4. Psarra, V.; Fousteris, M. A. *; Hennig, L.; Bantzi, M.; Giannis, A.; Nikolaropoulos, S. S. Identification of azepinone fused tetracyclic heterocycles as new chemotypes with protein kinase inhibitory activities. Tetrahedron 2016, 72, 2376-2385.
  5. Fousteris, M. A.; Schubert, U.; Roell, D.; Roediger, J.; Bailis, N.; Nikolaropoulos, S. S.; Baniahmad, A.; Giannis, A. 20-Aminosteroids as a novel class of selective and complete androgen receptor antagonists and inhibitors of prostate cancer cell growth. Bioorganic & Medicinal Chemistry 2010, 18, 6960-6969.
  6. Churruca, F.; Fousteris, M.; Ishikawa, Y.; Von Wantoch Rekowski, M.; Hounsou, C.; Surrey, T.; Giannis, A. A novel approach to indoloditerpenes by nazarov photocyclization: Synthesis and biological investigations of terpendole E analogues. Organic Letters 2010, 12, 2096-2099.
  7. Spyridonidou, K.; Fousteris, M.; Marazioti A.; Chatzianastasiou, A.; Papapetropoulos, A.; Nikolaropoulos, S. Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase. Bioorganic & Medicinal Chemistry Letters 2009, 19, 4810-4813.
  8. Fousteris, M. A.; Papakyriakou, A.; Koutsourea, A.; Manioudaki, M.; Lampropoulou, E.; Papadimitriou, E.; Spyroulias, G. A.; Nikolaropoulos, S. S. Pyrrolo[2,3-a]carbazoles as potential Cyclin Dependent Kinase 1 (CDK1) inhibitors. Synthesis, biological evaluation, and binding mode through docking simulations. Journal of Medicinal Chemistry 2008, 51, 1048-1052.

Office Hours for Students:

  • Monday, 12:00-15:00
  • Wednesday, 10:00-13:00