Secretariat Time Programme
Daily
12:00 - 13:30

sfe

Sophia Hatziantoniou

work phone: 2610 962319
Department of Pharmacy, Health Sciences School
e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it  
University of Patras, Rio 26504 GREECE  

EDUCATIONAL BACKGROUND
1993: Degree of School of Pharmacy, University of Athens, Greece
1995: License of Pharmaceutical Profession, Ministry of Health, Athens, Greece
1999: Ph.D. Diploma of the School of Pharmacy, University of Athens, Greece
 
SCIENTIFIC WORKSHOPS AND SEMINARS
2013: 1st Summer Training School on Thermal Analysis and Calorimetry: From Theory to Practice, Athens, Greece
2011: Dendrimers as composites of Advanced Drug Delivery Nano Systems: Biomedical applications. COST Action TD0802, Athens, Greece
2006: 18th mountain/Sea Liposome Workshop, Ameland, Holland
2003: Microencapsulation: Formulation and Process Technologies Workshop in 30th Annual Meeting & Exposition of the Controlled Release Society, Glasgow, UK
2003: Advanced Customer Seminar on Thermal Analysis (Mettler Toledo), Zurich, Switzerland
2005: Summer School: Methods in micro – nanotechnology and nanobiotechnology, National Centre for Scientific Research «Democritos», Greece
2007: Course on Laboratory Animal Science 24/9 – 5/10/, coordinated by the BSRC Alexander Fleming and the Dept of Laboratory Animal Science, Utrech University.
1998: Course on «Safety assessment of cosmetic products», Hellenic Society of Cosmetology, Athens, Greece
1995: Postgraduate six month Seminar of Pharmaceutical Marketing, School of Pharmacy, Athens, Greece
 
EXPERIENCE
Research experience:
Since 2000 Postdoctoral Researcher in the Laboratory of of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, on the following fields:
  • Preparation and physicochemical characterization of nanoparticles (liposomes, solid lipid nanoparticles,nanoemulsions and dendrimers) as carriers of biologically active substances for pharmaceutical or cosmetic products. Thermal Analysis (Differential Scanning Calorimetry) and Raman spectroscopy studies on interactions of biologically active substances with model lipid membranes and liposomes.
  • Development of several in vivo pharmacological models: 
    -on SCID NOD mice: development of xenografts for several cancer cell lines and anti-tumor activity assessment of natural products and liposomal drugs 
    -on SKH1 (hairless mice): anti-inflammatory activity assessment of natural products on UV induced skin barrier disruption models 
    -on albino rabbits: (Safety assessment of pharmaceutical and cosmetic products - eye irritation and skin irritation tests)
    in vitro Safety assessment of pharmaceutical and cosmetic products (HET-CAM tests).
SCIENTIFIC INTERESTS
  • Design and study of nanocarriers as transporters of biologically active molecules
  • Incorporation of drug molecules in nanosystems (liposomes, nanoemulsions, solid state lipid nanoparticles (SLN), polymeric systems, dendrimers), to improve the pharmacokinetic properties, bioavailability and pharmacological response in target tissues (tumors, lung , skin).
  • Formulation of novel carriers of bioactive molecules into final products and study their characteristics (size distribution, zeta-potential, particle surface morphology, content of actives and excipients, active bioavailability, stability).
  • Study of the interaction of bioactive molecules with model lipid membranes mainly by Thermal Analysis in order to design new formulations, as well as to predict their interaction with biological membranes.
  • Development of cosmetics and topical pharmaceutical product. Study of the physicochemical characteristics and stability. Safety assessment and evaluation of their efficacy using non-invasive biomechanical methods for claim substantiation.
Professional Affiliations
  • Hellenic Society of Cosmetology: Vice President and Founding Member (1995)
  • Hellenic Society for Thermal Analysis (ESTA): Secretary General
  • Hellenic Pharmaceutical Society (Assistant Secretary)
  • Panhellenic Association of Pharmacists (PEF)
  • Hellenic Society of Pharmaceutical Technology
  • Controlled Release Society (CRS) local Chapter
  • International Liposome Society (ILS)
Publications
  • Number of papers in refereed journals: 47
  • Number of chapters in books: 4
  • Number of communications in international scientific meetings: over 50
  • Number of Invited Lectures: 22
Selected Publications
  1. CAVEOLAR UPTAKE AND ENDOTHELIAL-PROTECTIVE EFFECTS OF NANOSTRUCTURED LIPID CARRIERS IN ACID ASPIRATION MURINE ACUTE LUNG INJURY KARDARA, M., HATZIANTONIOU, S., SFIKA, A., VASSILIOU, A.G., MOURELATOU, E., MAGKOU, C., ARMAGANIDIS, A., ROUSSOS, C., ARMAGANIDIS, A., ORFANOS, S.E., KOTANIDOU, A., MANIATIS, N.A. Pharmaceutical Research (2013) in press.
  2. PHYSICOCHEMICAL STABILITY ASSESSMENT OF ALL-IN-ONE PARENTERAL EMULSION FOR NEONATES CONTAINING SMOFLIPID SKOUROLIAKOU, M., KOUNTOURI, A.M., HATZIANTONIOU, S., KOUTRI, K., CHIOU, A European Journal of Hospital Pharmacy: Science and Practice. (2012) 19 (6): 514-518.
  3. TYPE AND LOCATION OF INTERACTION BETWEEN HYPERBRANCHED POLYMERS AND LIPOSOMES. RELEVANCE TO DESIGN OF A POTENTIALLY ADVANCED DRUG DELIVERY NANOSYSTEM (ADDNS). MOURELATOU EA, LIBSTER D, NIR I, HATZIANTONIOU S, ASERIN A, GARTI N, DEMETZOS C. J Phys Chem B. 2011 Apr 7;115(13):3400-8
  4. THERMODYNAMIC CHARACTERIZATION OF LIPOSOMAL–LOCKED IN-DENDRIMERS AS DRUG CARRIERS K. GARDIKIS, S. HATZIANTONIOU, M. SIGNORELLI, M. PUSCEDDU, M.MICHA-SCRETTAS, A. SCHIRALDI, C. DEMETZOS, D. FESSAS Colloids and Surfaces B: Biointerfaces 2010, 2010 Nov 1;81(1):11-9
  5. CHIMERIC ADVANCED DRUG DELIVERY NANO SYSTEMS (CHI-ADDNSS) FOR SHIKONIN COMBINING DENDRITIC AND LIPOSOMAL TECHNOLOGY. KONTOGIANNOPOULOS KN, ASSIMOPOULOU AN, HATZIANTONIOU S, KARATASOS K, DEMETZOS C, PAPAGEORGIOU VP. Int J Pharm. 2012 Jan 17;422(1-2):381-9
  6. MITOCHONDRIA-TARGETED LIPOSOMES IMPROVE THE APOPTOTIC AND CYTOTOXIC ACTION OF SCLAREOL N. R. PATEL, S. HATZIANTONIOU, A. GEORGOPOULOS, C. DEMETZOS, V. TORCHILLIN, V. WEISSIG, G.G.M. SOUZA Journal of Liposome Res. 2009, Nov.2.
  7. SOLID LIPID NANOPARTICLES AND NANOEMULSIONS CONTAINING CERAMIDES: PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION. G. DELI, S. HATZIANTONIOU, Y. NIKAS, C. DEMETZOS Journal of Liposome Res. 2009, 19, 180-188
  8. VISUALISATION OF LIPOSOMES PREPARED FROM SKIN AND STRATUM CORNEUM LIPIDS BY TRANSMISSION ELECTRON MICROSCOPY S. HATZIANTONIOU *, I. P. NEZIS, L. H. MARGARITIS , C. DEMETZOS Micron. 2007, 38, 777-781
  9. QUALITATIVE AND QUANTITATIVE ONE STEP ANALYSIS OF LIPIDS AND ENCAPSULATED BIOACTIVE MOLECULES IN LIPOSOME PREPARATION BY HPTLC/FID (IATROSCAN) S. HATZIANTONIOU, C. DEMETZOS Journal of Liposome Research. 2006, 16, 321-330
  10. A DSC AND RAMAN SPECTROSCOPY STUDY ON THE EFFECT OF PAMAM DENDRIMER ON DPPC MODEL LIPID MEMBRANES. K. GARDIKIS , S. HATZIANTONIOU , K. VIRAS , M. WAGNER , C. DEMETZOS Int. J Pharm. 2006, 318, 118-123.
  11. PHASE TRANSITION OF LIPIDS AND LIPOSOMES S. HATZIANTONIOU, C. DEMETZOS, M. WAGNER UserCom,Mettler-Toledo. 2005, 1, 16-19.
  12. CYTOTOXIC AND ANTITUMOR ACTIVITY OF LIPOSOME-INCORPORATED SCLAREOL AGAINST CANCER CELL LINES AND HUMAN COLON CANCER XENOGRAFTS S. HATZIANTONIOU, K. DIMAS, A. GEORGOPOULOS, N.SOTIRIADOU , C. DEMETZOS Pharmacological Res. 2006, 53, 80-87.