Secretariat Time Programme
Daily
12:00 - 13:30

sfe

Plato A. Magriotis
Tel. : (+302610) 962311
Fax :
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it


Education
1983-1986: Postdoctoral Fellow ; Harvard University, USA
1983: Ph.D. in Chemical Biology; SUNY at Stony Brook, USA
1978: B.Sc. in Chemistry, University of Athens, Greece

Academic Experience
2006-present: Associate Professor; Pharmaceutical Chemistry, Department of Pharmacy, University of Patras.
2001-2006: Adjunct Professor; Chemistry, Department of Chemistry, New York University.
1995-1996: Merck Research Fellow; Chemistry, Department of Chemistry and Chemical Biology, Harvard University.
1986-1995: Assistant Professor; Chemistry, Department of Chemistry, West Virginia University.

Industrial Experience
1996-2001: Research Fellow; Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ

Research Interests
  • Synthesis of biologically and pharmacologically relevant molecules such as a- and b-amino acids, b-lactams, piperidines, and piperazines.
  • Total Synthesis of antitumor, antibiotic Natural Products (Cyclostreptin-(-)-FR182877, Ecteinascidin 743, Saframycin A, and Abyssomicin C).
  • New Synthetic Methodology including novel routes to b-lactams, piperazines and tetrasubstituted olefins (Tamoxifen analogs).


Undergraduate Courses
Organic Chemistry. (P. Cordopatis, S. Nikolaropoulos) ΦΠ-122.
Medicinal Chemistry III. ΦΠ-322.

Graduate Courses
Postgraduate Program in “Pharmaceutical Sciences and Technology”, Department of Pharmacy-University of Patras

Modern Approaches in Medicinal Chemistry (ΦΜ-Α03) C. Camoutsis, P. Magriotis, S. Nikolaropoulos, G. Pairas, M. Fousteris
Advanced Topics in Organic Synthesis (ΦΜ-Α04) P. Cordopatis, V. Magafa, P. Magriotis, S. Nikolaropoulos, M. Fousteris

Recent Selected Publications

  • "Importance of Mechanistic Drug Metabolism Studies in Support of Drug Discovery: A Case Study with a N-Sulfonylated dipeptide VLA-4 Antagonist in Rats" Tang, W.; Stearns, R. A.; Chen, Q.; Bleasby, K.; Teffera, Y.; Colletti, A.; Hafey, M.; Evers, R.; Dean, D. C.; Μagriotis, P. A.; Lanza, T.J.; Lin, L.S.; Hagmann, W.K.; Baillie, T.A. Xenobiotica 2008, 38, 223-237.
  • “A Simple Synthesis of the Metabotropic Receptor Ligand (2S)-a-(Hydroxyymethyl)- glutamic acid and its Fmoc Protected Derivatives” Yiotakis A.; Magriotis, P. A.; Vassiliou, S. Tetrahedron: Asymmetry 2007, 18, 873-877.
  • “ Efficient Enantioselective Synthesis of Orthogonally Protected (R)-a-Alkylserines Compatible with the Solid Phase Peptide Synthesis” Vassiliou, S.; Yiotakis, A.; Magriotis, P. A. Tetrahedron Letters 2006, 47, 7339-7341.
  • “ Improved Schöllkopf Construction of Quaternary a-Amino Acids: Efficient Enantioselective Synthesis of Integrin LFA-1 Antagonist BIRT-377” Vassiliou, S.; Magriotis, P. A. Tetrahedron: Asymmetry 2006, 17, 1754-1757.
  • “Anew Method for the Functionalization of [60] Fullerene: An Unusual 1,3-Dipolar Cycloaddition Leadind to a C60 Housane Derivative” Zhou, Z., Magriotis, P. A. Org. Lett. 2005, 7, 5849-5851.
  • “Novel Applications of the Schöllkopf Chiral Auxiliary: A New and Efficient Enantioselective Synthesis of b-Lactams Possessing a C-4 Quaternary Stereocenter” Vassiliou, S.; Dimitropoulos, C.; Magriotis, P. A. Synlett 2003, 2398-2400.
  • N-Tetrahydrofuroyl-(L)-Phenylalanine Derivatives As Potent VLA-4 Antagonists” Yang, G. X.; Chang, L. L.; Truong, Q.; Doherty, G. A.; Magriotis, P. A.; de Laszlo, S. E.; Li, B.; MacCoss, M.;Kidambi, U.; Egger, L. A.; McCauley, E.; Van Riper, G.; Mumford, R. A.; Schmidt, J. A.; Hagmann, W. K. Bioorg. Med. Chem. Lett. 2002, 12, 1497-1500.
  • “Recent Progress in the Enantioselective Synthesis of b-Lactams: Development of the first Catalytic Approaches” Magriotis, P. A. Angew. Chem., Int. Ed. Engl. 2001, 40, 4377-437\