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Avgoustakis Konstantinos PDF Print
Tel. : (+302610) 962317 | 962318
Fax : (+302610) 997690

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Web: http://www.pharmacy.upatras.gr/index.php/el/personell/meli-dep/-mainmenu-40/25-avgoustakis-konstantinos

EMPLOYMENT
2008 – today: Professor in University of Patras, Department of Pharmacy, Pharmaceutical Technology Lab., Rio 26 500, Patras, Greece
2000 - 2008: Assistant Professor in University of Patras, Department of Pharmacy, Pharmaceutics Lab., Rio 26 500, Patras, Greece
1994 - 2000: Lecturer in the Department of Pharmacy, University of Patras.
1993 - 1994 : Research assistant in Institute of Radioisotopes and Radiodiagnostic Products, NCSR "Demokritos", Athens, Greece

AFFILIATIONS

  • European Federation of Pharmaceutical Scientists (EUFEPS)
  • Controlled Release Society (CRS)
  • European Society for Nanomedicine

EDUCATION
1985:
Bsc in Pharmacy, Aristotle University of Thessaloniki, Greece
1991: Ph.D. in Pharmaceutics/Quality Control of Drugs, Aristotle University of Thessaloniki, Greece
1992: Ph.D. in Pharmaceutics, London University, England

SCHOLARSHIPS
- University of Thessaloniki (for postgraduate studies, 1986-1989)
- Greek State Scholarships Foundation (for PhD studies abroad, 1989-1992)

FIELD OF EXPERTISE

  • Pharmaceutics and Biopharmaceutics
  • Pharmaceutical Nanotechnology
TEACHING ACTIVITIES
Undergraduate Program (Department of Pharmacy)
  • Pharmaceutical Technology I (Industrial Pharmacy)
  • Pharmaceutical Technology II (Drug Delivery Systems)
  • Chemistry and Technology of Cosmetics
Postgraduate Program (Department of Pharmacy) 
  • Controlled Drug Delivery Systems-Pharmaceutical Nanotechnology
  • Advanced Pharmaceutical Technology (Advanced Courses on Solid Dosage Forms)
  • Basic Pharmaceutical Statistics
RESEARCH INTERESTS
  • Targeted delivery of anticancer drugs based on i) biodegradable, polymeric, long-circulating (“stealth”) nanoparticles and ii) magnetic hybrid nanoparticles,
  • Development of novel prophylactic or therapeutic vaccines based on biodegradable and biocompatible, polymeric nano- and micro-particles,
  • Development of formulations for the efficient delivery of drugs with limited aqueous solubility
RESEARCH GRANTS
  1. Project NANOBILON 09ΣΥΝ-41-659: “Development of novel ixabepilone nanocarriers and study of their potential in breast cancer treatment” (Principal Investigator, Project financed by Greek Secretariat for Research and Technology, budget 1 ME, period 2010-2013)
  2. Project MIS 380212 “Development of Multi-Functional Magnetic Nanoparticles for Targeted Delivery of Anticancer Drugs” (Principal Investigator, Project financed by Greek Secretariat for Research and Technology, budget 600 KE, period 2012-2014)
  3. Greek-Czech bilateral project 11CZ_026_EPAN2 “Hybrid Μagnetic "Stealth" Nano-Structures for the Targeted and Controlled Release of Doxorubicin” ((Principal Investigator, Project financed by Greek Secretariat for Research and Technology, budget of Greek partner 15 KE, period 2012-2013)

POST- GRADUATE STUDENTS SUPERVISSION
5 Ph.D. and 8 M.Sci. theses concluded so far in the research field of controlled drug delivery and pharmaceutical nanotechnology.

EDITORIAL ACTIVITIES:

  1. Assistant Editor for Current Nanoscience (Bentham Science Publishers).
  2. Editorial Board Member for Current Nanoscience (Bentham Science Publishers).
  3. Editorial Board Member for Open Drug Delivery Journal (Bentham Science Publishers).
  4. Editorial Board Member for Journal of Excipients and Food Chemicals (Published by International Pharmaceutical Excipients Council)

PUBLICATIONS
Research papers : 50
Articles in Biomedical Encyclopedia: 1
Presentations in International Scientific Conferences: 35
Patents: 1 European Patent, 2 Greek patents
Index h (Scopus): 17
Non-self citations (Scopus): 1313

Recent Publications in peer-reviewed Journals (2013 - 2009)

  1. Athanassios Giarmoukakis, Georgios Labiris, Haris Sideroudi, Zinovia Tsimali, Nefeli Koutsospyrou, Konstantinos Avgoustakis, Vassilios Kozobolis, Biodegradable nanoparticles for controlled subconjunctival delivery of latanoprost acid: In vitro and in vivo evaluation. Preliminary results, Experimental Eye Research 112 (2013) 29-36.
  2. Dimitra Hadjipavlou-Litina, George E. Magoulas,Stavros E. Bariamis, Zinovia Tsimali, Konstantinos Avgoustakis, Christos A. Kontogiorgis, Constantinos M. Athanassopoulos, Dionissios Papaioannou, Synthesis and evaluation of the antioxidative potential of minoxidil–polyamine conjugates, Biochimie 95 (2013) 1437–1449.
  3. Bariamis, S.E., Marin, M., Athanassopoulos, C.M., Kontogiorgis, C., Tsimali, Z., Papaioannou, D., Sindona, G., Romeo, G., Avgoustakis, K., Hadjipavlou-Litina, D. Syntheses and evaluation of the antioxidant activity of novel methoxypsoralen derivatives, European Journal of Medicinal Chemistry 60 (2013) 155-169.
  4. Aristides Bakandritsos, Aristeidis Papagiannopoulos, Eleni N. Anagnostou, Konstantinos Avgoustakis, et al., Merging High Doxorubicin Loading with Pronounced Magnetic Response and Bio-repellent Properties in Hybrid Drug Nanocarriers, Small, 8 (2012) 2381-2393.
  5. G.E. Magoulas, T. Garnelis, C.M. Garnelis, C.M. Athanassopoulos, D. Papaioannou, G. Mattheolabakis, K. Avgoustakis, D. Hatzipavlou-Litina, Synthesis and antioxidative/anti-inflammatory activity of novel fullerene-polyamine conjugates, Tetrahedron, Tetrahedron 68 (2012) 7041-7049.
  6. Mingguang Li, Zoi Panagi, Konstantinos Avgoustakis, Joshua Reineke, Physiologically Based Pharmacokinetic modeling of PLGA Nanoparticles with varied mPEG content, Int.J. Nanoscience, 7, 2012,1345-1356.
  7. Zacharoula Iatridi, George Mattheolabakis, Konstantinos Avgoustakis, and Constantinos Tsitsilianis, Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers, Soft Matter, 7, 2011, 11160-11168
  8. Aristides Bakandritsos, George Mattheolabakis, George Chatzikyriakos, Tamas Szabo, Vasilis Tzitzios, Dimitris Kouzoudis, Stelios Couris, Konstantinos Avgoustakis, “Doxorubicin Nanocarriers Based on Magnetic Colloids with a bio-Polyelectrolyte Corona and High non-linear Optical Response: Synthesis, Characterization and Properties”, Advanced Functional Materials, 21, 2011, 1465-1475.
  9. Spiridoula Kyriakopoulou, George Mattheolabakis, Sofia Papadimitriou, Evangelos Karavas, Dimitrios Bikiaris, Konstantinos Avgoustakis, “PPSu-PEG copolymers and their application in the preparation of cisplatin-loaded nanoparticles”, Current Nanoscience 7, 2011, 503-509.
  10. Dimitra Hadjipavlou-Litina, George E. Magoulas, Stavros E. Bariamis, Denis Drainas, Konstantinos Avgoustakis, Dionissios Papaioannou, Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?, Bioorganic & Medicinal Chemistry 18, 2010, 8204-8217.
  11. A.A. Vassiliou, S. A. Papadimitriou, D. N. Bikiaris, G. Mattheolabakis and K. Avgoustakis, “Facile synthesis of polyester-PEG triblock copolymers and preparation of amphiphilic nanoparticles as drug carriers”, J. Control. Rel., 148, 2010, 388-395.
  12. Blatsios G, Tzimas A, George Mattheolabakis, Zoi Panagi, Konstantinos Avgoustakis, Gartaganis SP, “Development of biodegradable controlled release scleral systems of Triamcinolone acetonide”, Current Eye Research, 35, 2010, 916-924.
  13. Konstantinos P. Koutroumanis, Konstantinos Avgoustakis, Dimitrios Bikiaris, “Synthesis of crosslinked N-(2-carboxybenzyl)chitosan pH sensitive polyelectrolyte and its use for drug controlled delivery”, Carbohydrate Polymers, 82, 2010, 181-188.
  14. Aristides Bakandritsos, George Mattheolabakis, Radek Zboril, Nikolaos Bouropoulos, Dimitrios Fatouros, Jiri Tucek, Konstantinos Avgoustakis, “Preparation, Stability and Cytocompatibility of Magnetic/PLA-PEG Hybrids ”, Nanoscale, 2, 2010, 564–572.
  15. George Mattheolabakis, George Lagoumintzis, Zoi Panagi, Evangelia Papadimitriou, Charalambos D. Partidos, Konstantinos Avgoustakis, “Immune stimulation after transcutaneous delivery with antigen-loaded PLA nanoparticles”, Int. J. of Pharm., 385, 2010, 187-193.
  16. K. Avgoustakis, “Engineered polymers and polymeric systems in controlled drug delivery and targeting”, Ε.J. Pharm. Biopharm., 71, 2009, 407-408.
  17. Dimitrios N. Bikiaris, George Z. Papageorgiou, Sofia A. Papadimitriou, Evangelos Karavas, Konstantinos Avgoustakis, «Novel biodegradable polyester poly(propylene succinate): Synthesis and application in the preparation of solid dispersions and nanoparticles of a water soluble drug», AAPS PharmSciTech., 10, 2009, 138-145.
  18. George Mattheolabakis, Zoi Panagi, Era Taoufik, Michael Roberts, Konstantinos Avgoustakis, “In vivo investigation of toxicity and antitumor activity of cisplatin-loaded PLGA-mPEG nanoparticles”, Ε.J. Pharm. Biopharm., 71, 2009, 190-195.