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Avgoustakis Konstantinos PDF Print
Tel. : (+302610) 962317 
Fax : (+302610) 969180

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Web: http://www.pharmacy.upatras.gr/index.php/el/personell/meli-dep/-mainmenu-40/25-avgoustakis-konstantinos

http://www.bioacademy.gr/faculty-details/HMuF/konstantinos?lang=en 

EMPLOYMENT

2015 – today: Professor in University of Patras, Department of Pharmacy,
2015 – today: Affiliated Investigator in Biomedical Research Foundation, Academy of Athens, Greece,
2008 – 2015: Associate Professor in University of Patras, Department of Pharmacy, Pharmaceutics Lab., Rio 26 500, Patras, Greece
2000 - 2008: Assistant Professor in University of Patras, Department of Pharmacy, Pharmaceutics Lab., Rio 26 500, Patras, Greece
1994-2000: Lecturer in the Department of Pharmacy, University of Patras.
1993-1994 : Research assistant in Institute of Radioisotopes and Radiodiagnostic Products, NCSR "Demokritos", Athens, Greece

EDUCATION

1985: BSc in Pharmacy, University of Thessaloniki
1991: Ph.D. in Pharmaceutics/Quality Control of Drugs, University of Thessaloniki
1992: Ph.D. in Pharmaceutics, London University

SCHOLARSHIPS

  • University of Thessaloniki (for postgraduate studies, 1986-1989) 
  • Greek State Scholarships Foundation (for PhD studies abroad, 1989-1992) 

AFFILIATIONS

  • European Society for Nanomedicine 
  • Controlled Release Society (CRS)  

FIELD OF EXPERTISE

  • Pharmaceutics and Biopharmaceutics 
  • Pharmaceutical Nanotechnology 

TEACHING ACTIVITIES

Undergraduate Program (Department of Pharmacy)

  • Pharmaceutical Technology I (Industrial Pharmacy) 
  • Pharmaceutical Technology II (Drug Delivery Systems) 
  • Chemistry and Technology of Cosmetics 

Postgraduate Program (Department of Pharmacy)

  • Controlled Drug Delivery Systems-Pharmaceutical Nanotechnology 
  • Advanced Pharmaceutical Technology 
  • Basic Pharmaceutical Statistics 

 POST- GRADUATE STUDENTS SUPERVISION

  •  5 Ph.D. and 18 M.Sci. (masters) degrees concluded so far in the subject of controlled drug delivery and pharmaceutical nanotechnology. 

EDITORIAL ACTIVITIES:

  1. Assistant Editor for Current Nanoscience (Bentham Science Publishers). 
  2. Editorial Board Member for Current Nanoscience (Bentham Science Publishers). 
  3. Editorial Board Member for Journal of Excipients and Food Chemicals (Published by International Pharmaceutical Excipients Council) 

Guest Editing 

  • Guest Editor of special issue of Journal European Journal of Pharmaceutics and Biopharmaceutics (Elsevier) on “Engineered polymers and polymeric systems in controlled drug delivery and targeting”, 2009 

OTHER SCIENTIFIC ACTIVITIES

  • Assessor of files for medicines for human use for the Greek National Medicines Organization (EOF) and EMA 
  • EMA expert (The European Medicines Agency (EMA) maintains a public list containing details on selected European experts who can be involved in the Agency's work in the context of the authorisation, supervision and maintenance of medicinal products for human or veterinary use) 

RESEARCH INTERESTS

  • Targeted delivery of anticancer drugs based on i) biodegradable, polymeric, long-circulating (“stealth”) nanoparticles and ii) magnetic hybrid organic-inorganic nanoparticles, 
  • Development of novel prophylactic or therapeutic vaccines based on biodegradable and biocompatible, polymeric nano- and micro-particles,  
  • Development of formulations for the efficient delivery of drugs with limited aqueous solubility 

RESEARCH GRANTS (2010-)

  • Project NANOBILON 09ΣΥΝ-41-659: “Development of novel ixabepilone nanocarriers and study of their potential in breast cancer treatment” (Principal Investigator, Project financed by Greek Secretariat for Research and Technology, budget 1 ME, period 2010-2013)  
  • Project MIS 380212 “Development of Multi-Functional Magnetic Nanoparticles for Targeted Delivery of Anticancer Drugs” (Principal Investigator, Project financed by Greek Secretariat for Research and Technology, budget 600 KE, period 2012-2014) 
  • Greek-Czech bilateral project 11CZ_026_EPAN2 “Hybrid Μagnetic "Stealth" Nano-Structures for the Targeted and Controlled Release of Doxorubicin” (Principal Investigator, Project financed by General Secretariat for Research and Technology (GSRT), budget of Greek partner 15 KE, period 2012-2013).
  • Post-doctoral fellowship supervisor for the project “Combination treatment of hypoxic cancer tumors using radiation and targeting glucose transfer inhibitors” (Fellow Dr. Athina Angelopoulou) National State Scholarships Foundation (IKY) Fellowships of Excellence for Postgraduate Studies in Greece, budget 12KE, period 2015-1016. 
  • Project EATRIS-GR: Infrastructure for Preclinical and Early-Phase Clinical Development of Drugs, Therapeutics and BioMedical Devices, funding from the “Greek National Program for Research Infrastructures” of the General Secretariat for Research & Technology (GSRT) (Coordinator for University of Patras, budget 500 KE, period 2018-2020). 
  • Project MIS 5025034 “Folic acid-functionalized, structurally-condensed magnetic nanoparticles of doxorubicin for targeted treatment of tumors overexpressing the folate receptor” funded by Greek State and European Social Fund in the context of National Program for Regional Development (Principal Investigator, budget 63 KE, period 2018-2020). 

PUBLICATIONS/PRESENTATIONS

  1. Peer-reviewed journals: 63 
  2. Biomedical Encyclopedia: 1 
  3. Inernational Scientific Conferences: 44 
  4. Greek Scientific Conferences: 27 
  5. Patents: 1 (European) 

Citations (Google Scholar) 2017: 3110, h-index 25.

PUBLICATIONS (Peer-reviewed journals)

  1. Avgoustakis, K. and Nixon, J.R., Biodegradable controlled release tablets: 1. Preparative variables affecting the properties of poly(lactide-co-glycolide) copolymer as matrix forming material. Int. J. Pharm., 79 (1991) 77-85. 
  2. Avgoustakis, K. and Niopas, I., “Dissolution and bioavailability evaluation of three brands of paracetamol tablets”. Epitheorese klinikes Farmacologias Farmakokinetikes, International Edition, 5 (1991) 58-61. 
  3. Avgoustakis, K., Athanasiou, A. and Georgakopoulos, P.P., “Effect of helix characteristics on the dissolution rate of hard gelatin capsules. Int. J. Pharm., 79 (1992) 67-69.  
  4. Malamataris, S., Goidas, P. and Avgoustakis, K., “Comparative evaluation of soy polysaccharide as direct compression excipient”. Drug Dev. Ind. Pharm., 18 (1992) 1575-1587. 
  5. Avgoustakis, K. and Nixon, J.R., Biodegradable controlled release tablets: II. Preparation and properties of poly(lactide-co-glycolide) powders. Int. J. Pharm., 99 (1993) 239-246. 
  6. Avgoustakis, K. and Nixon, J.R., Biodegradable controlled release tablets: III. Effect of polymer characteristics on drug release from heterogeneous poly(lactide-co-glycolide) matrices. Int. J. Pharm., 99 (1993) 247-252. 
  7. Panagi, Z., Sawas-Dimopoulou, C., Avgoustakis, K. and Ithakissios, D.S., Αpplication of 99mTc-labeling for comparative screening of Preformed liposomes In Vivo. Drug. Dev. Ind. Pharm. 22 (1996) 217-224. 
  8. Z. Panagi, K. Avgoustakis, G. Evangelatos and D.S. Ithakissios. Protein induced CF release kinetics from liposomes in vitro and its correlation with the BLOOD/RES biodistribution of liposomes. Int. J. Pharm., 163 (1998) 103-114. 
  9. Z. Panagi, K. Avgoustakis, G. Evangelatos and D.S. Ithakissios. In vitro binding of HSA, IgG and HDL on liposomes and its correlation with the in vivo BLOOD/RES ratio of liposomes. Int. J. Pharm., 176(1999) 203-207.  
  10. A. Beletsi, L. Leontiadis, P. Klepetsanis, D. S. Ithakissios and K. Avgoustakis. Effect of preparative variables on the properties of PLGA-mPEG copolymers related to their application in controlled drug delivery. Int. J. Pharm., 182(1999) 187-197. 
  11. Z. Panagi., A. Beletsi, G. Evangelatos, E. Livaniou, D. S. Ithakissios, and K. Avgoustakis. Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA-mPEG nanoparticles. Int. J. Pharm., 221(2001) 143-152. 
  12. V. Koutrafouri, L. Leondiadis, K. Avgoustakis, E. Livaniou, J. Czarnecki, D.S. Ithakissios and G.P. Evangelatos, Effect of thymosin peptides on the chick chorioallantoic membrane angiogenesis model, Biochim Biophys Acta, 1568(2001) 60-66.  
  13.  K. Avgoustakis, A. Beletsi, Z. Panagi, P. Klepetsanis, A.G. Karydas, and D.S. Ithakissios, PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties, J Control Release, 79(2002) 123-135. 
  14. V. Koutrafouri, L. Leondiadis, N. Ferderigos, K. Avgoustakis, E. Livaniou, G. P. Evangelatos and D.S. Ithakissios, Synthesis and angiogenetic activity in the chick chorioallantoic membrane model of thymosin beta 15, Peptides 24 (2003) 107-115. 
  15. K. Avgoustakis, A. Beletsi, Z. Panagi, P. Klepetsanis, E. Livaniou, G. Evangelatos and D. S. Ithakissios, Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA–mPEG nanoparticles. Int. J. Pharm., 259 (2003) 115-127.  
  16. N. Charalampopoulos, K. Avgoustakis, C. Kontoyannis, Differential pulse polarography: A suitable technique for monitoring drug release from polymeric nanoparticle dispersions. Analytica Chimica Acta, 491 (2003) 57-62. 
  17. N. Stivaktakis, K. Nikou, Z. Panagi, A. Beletsi, L. Leondiadis, K. Avgoustakis, PLA and PLGA microspheres of β-galactosidase: Effect of formulation factors on protein antigenicity and immunogenicity, J. Biomed. Mater. Res. A., 70 (2004) 139-148. 
  18. K. Avgoustakis, Pegylated Poly(Lactide) and Poly(lactide-co-glycolide) Nanoparticles: Preparation, Properties and Possible Applications in Drug Delivery, Current Drug Delivery, 1 (2004) 321-333. 
  19. N. Stivaktakis, K. Nikou, Z. Panagi, A. Beletsi, L. Leondiadis, K. Avgoustakis, Immune responses in mice of β-galactosidase adsorbed or encapsulated in PLA and PLGA microspheres, J. Biomed. Mater. Res. A., 73 (2005) 332-338. 
  20. A. Beletsi, Z. Panagi and K. Avgoustakis, “Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA–PEG diblock copolymers” Int. J. Pharm., 298 (2005) 233-241. 
  21. E. Pierri, K. Avgoustakis, ‘Poly(lactide)-poly(ethylene glycol) micelles as a carrier for griseofulvin’, J. Biomed. Mater. Res. A., 75 (2005) 639-647.  
  22. K. Nikou, N. Stivaktakis, K. Avgoustakis, P. A. Sotiropoulou, S. A. Perez, C.N. Baxevanis, M. Papamichail, L. Leondiadis, “A HER-2/neu peptide admixed with PLA microspheres induces a Th1 biased immune response in mice” Biochim Biophys Acta, 1725 (2005) 182-189. 
  23. G. Katsikogianni, K. Avgoustakis, ‘PLGA-mPEG nanoparticles: Drug loading and release properties’, J. Nanoscience Nanotechnology, 6 (2006) 3080-3086. 
  24. E. C. Gryparis, G. Mattheolampakis, D. Bikiaris, K. Avgoustakis, “Effect of Conditions of Preparation on the Size and Encapsulation Properties of PLGA-mPEG Nanoparticles of Cisplatin” Drug Delivery, 14 (2007) 371-380.  
  25. E. C. Gryparis, M. Hatziapostolou, E. Papadimitriou, K. Avgoustakis, “Anticancer activity of cisplatin-loaded PLGA-mPEG nanoparticles on LNCaP prostate cancer cells” Ε.J. Pharm. Biopharm., 67 (2007):1-8. 
  26.  (26) E. Karavas, E. Georgarakis, M. P. Sigalas, V. I. Teberekidis, K. Avgoustakis, D. Bikiaris, “Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactions” Ε.J. Pharm. Biopharm., 66 (2007) 334-347. 
  27. M. Efentakis, I. Pagoni, M. Vlachou, K. Avgoustakis, “Dimensional changes, gel layer evolution and drug release studies in hydrophilic matrices loaded with drugs of different solubility” Int. J. Pharm. 339 (2007) 66-75. 
  28. Sofia Papadimitriou, Dimitrios Bikiaris, Konstantinos Avgoustakis. “Microwave-induced enhancement of dissolution rate of the poorly water-soluble Tibolone from solid dispersions” J. Appl. Polymer Sci., 108 (2008) 1249-1258. 
  29. Sofia Papadimitriou, Dimitrios Bikiaris, Konstantinos Avgoustakis, Evangelos Karavas, Manolis Georgarakis, “Chitosan nanoparticles loaded with dorzolamide and pramipexole”, Carbohydrate Polymers 73(2008) 44-54. 
  30. A Beletsi, P. Klepetsanis, D.S. Ithakissios, S. Kounias, A. Stavropoulos and K. Avgoustakis, “Simultaneous optimization of cisplatin-loaded PLGA-mPEG nanoparticles with regard to their size and drug encapsulation”, Current Nanoscience 4 (2008) 173-178. 
  31. George Mattheolabakis, Zoi Panagi, Era Taoufik, Michael Roberts, Konstantinos Avgoustakis, “In vivo investigation of toxicity and antitumor activity of cisplatin-loaded PLGA-mPEG nanoparticles” Ε.J. Pharm. Biopharm., 71, 2009, 190-195).  
  32. Dimitrios N. Bikiaris, George Z. Papageorgiou, Sofia A. Papadimitriou, Evangelos Karavas, Konstantinos Avgoustakis, Novel biodegradable polyester poly(propylene succinate): Synthesis and application in the preparation of solid dispersions and nanoparticles of a water soluble drug, AAPS PharmSciTech., 10, 2009, 138-145. 
  33. K. Avgoustakis, “Engineered polymers and polymeric systems in controlled drug delivery and targeting” Ε.J. Pharm. Biopharm., 71, 2009, 407-408. 
  34. George Mattheolabakis, George Lagoumintzis, Zoi Panagi, Evangelia Papadimitriou, Charalambos D. Partidos, Konstantinos Avgoustakis, “Immune stimulation after transcutaneous delivery with antigen-loaded PLA nanoparticles” Int. J. of Pharm., 385, 2010, 187-193. 
  35. Aristides Bakandritsos, George Mattheolabakis, Radek Zboril, Nikolaos Bouropoulos, Dimitrios Fatouros, Jiri Tucek, Konstantinos Avgoustakis, “Preparation, Stability and Cytocompatibility of Magnetic/PLA-PEG Hybrids ”, Nanoscale, 2010, 2, 564–572. 
  36. Konstantinos P. Koutroumanis, Konstantinos Avgoustakis, Dimitrios Bikiaris, “Synthesis of crosslinked N-(2-carboxybenzyl)chitosan pH sensitive polyelectrolyte and its use for drug controlled delivery”, Carbohydrate Polymers, 82, 2010, 181-188. 
  37. Blatsios G, Tzimas A, George Mattheolabakis, Zoi Panagi, Konstantinos Avgoustakis, Gartaganis SP, “Development of biodegradable controlled release scleral systems of Triamcinolone acetonide”, Current Eye Research, 35, 2010, 916-924. 
  38. A.A. Vassiliou, S. A. Papadimitriou, D. N. Bikiaris, G. Mattheolabakis and K. Avgoustakis, “Facile synthesis of polyester-PEG triblock copolymers and preparation of amphiphilic nanoparticles as drug carriers”, J. Control. Rel., 148 , 2010, 388-395. 
  39. Dimitra Hadjipavlou-Litina, George E. Magoulas, Stavros E. Bariamis, Denis Drainas, Konstantinos Avgoustakis, Dionissios Papaioannou, Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?, Bioorganic & Medicinal Chemistry 18, 2010, 8204-8217. 
  40. Spiridoula Kyriakopoulou, George Mattheolabakis, Sofia Papadimitriou, Evangelos Karavas, Dimitrios Bikiaris, Konstantinos Avgoustakis, “PPSu-PEG copolymers and their application in the preparation of cisplatin-loaded nanoparticles”, Current Nanoscience, 7, 2011, 503-509. 
  41. Aristides Bakandritsos, George Mattheolabakis, George Chatzikyriakos, Tamas Szabo, Vasilis Tzitzios, Dimitris Kouzoudis, Stelios Couris, Konstantinos Avgoustakis, “Doxorubicin Nanocarriers Based on Magnetic Colloids with a bio-Polyelectrolyte Corona and High non-linear Optical Response: Synthesis, Characterization and Properties”, Advanced Functional Materials, 21, 2011, 1465-1475. 
  42. Zacharoula Iatridi, George Mattheolabakis, Konstantinos Avgoustakis, and Constantinos Tsitsilianis, Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers, Soft Matter, 2011, 7, 11160-11168. 
  43. Mingguang Li, Zoi Panagi, Konstantinos Avgoustakis, Joshua Reineke, Physiologically Based Pharmacokinetic modeling of PLGA Nanoparticles with varied mPEG content, Int. J. Nanosc., 2012, 7, 1345-56.  
  44. Aristides Bakandritsos, Aristeidis Papagiannopoulos, Eleni N. Anagnostou, Konstantinos Avgoustakis, Radek Zboril, Stergios Pispas, Jiri Tucek, Vasyl Ryukhtin, Nikolaos Bouropoulos, Argiris Kolokithas-Ntoukas, Theodore A. Steriotis, Uwe Keiderling and Frank Winnefeld, Merging High Doxorubicin Loading with Pronounced Magnetic Response and Bio-repellent Properties in Hybrid Drug Nanocarriers, Small, 8 (2012) 2381-2393. 
  45. G.E. Magoulas, T. Garnelis, C.M. Garnelis, C.M. Athanassopoulos, D. Papaioannou, G. Mattheolabakis, K. Avgoustakis, D. Hatzipavlou-Litina, Synthesis and antioxidative/anti-inflammatory activity of novel fullerene-polyamine conjugates, Tetrahedron, 68 (2012) 7041-7049. 
  46. Bariamis, S.E., Marin, M., Athanassopoulos, C.M., Kontogiorgis, C., Tsimali, Z., Papaioannou, D., Sindona, G., Romeo, G., Avgoustakis, K., Hadjipavlou-Litina, D. Syntheses and evaluation of the antioxidant activity of novel methoxypsoralen derivatives, European Journal of Medicinal Chemistry 60 (2013) 155-169. 
  47. Dimitra Hadjipavlou-Litina, George E. Magoulas,Stavros E. Bariamis, Zinovia Tsimali, Konstantinos Avgoustakis, Christos A. Kontogiorgis, Constantinos M. Athanassopoulos, Dionissios Papaioannou, Synthesis and evaluation of the antioxidative potential of minoxidil–polyamine conjugates, Biochimie 95 (2013) 1437–1449. 
  48. Athanassios Giarmoukakis, Georgios Labiris, Haris Sideroudi, Zinovia Tsimali, Nefeli Koutsospyrou, Konstantinos Avgoustakis, Vassilios Kozobolis, Biodegradable nanoparticles for controlled subconjunctival delivery of latanoprost acid: In vitro and in vivo evaluation. Preliminary results, Experimental Eye Research 112 (2013) 29-36. 
  49. Giorgio Zoppellaro, Argiris Kolokithas-Ntoukas, Katerina Polakova, Jiri Tucek, Radek Zboril, George Loudos, Eirini Fragogeorgi, Clemens Diwoky, Katerina Tomankova, Konstantinos Avgoustakis, Dimitris Kouzoudis, and Aristides Bakandritsos, Theranostics of Epitaxially Condensed Colloidal Nanocrystal Clusters through a Soft Biomineralization Route, Chemistry of Materials 26 (2014) 2062-2074. 
  50. Vassilios Karavelidis, Dimitrios Bikiaris, Konstantinos Avgoustakis, New thermosensitive nanoparticles prepared by biocompatible pegylated aliphatic polyester block copolymers for local cancer treatment, Journal of Pharmacy and Pharmacology, 67 (2015) 215-230. 
  51. George E. Magoulas, Marina Bantzi, Danai Messari, Efstathia Voulgari, Chrisostomi Gialeli, Despoina Barbouri, Athanassios Giannis, Nikos K. Karamanos, Dionissios Papaioannou, and Konstantinos Avgoustakis, Synthesis and Εvaluation of Αnticancer Αctivity in Cells of Novel Stoichiometric Pegylated Fullerene-Doxorubicin Conjugates, Pharmaceutical Research, 32 (2015) 1676-1693. 
  52. P.Mehta, L.Justo, S.Walsh, M.S.Arshad, C. G. Wilson, C.K.O’Sullivan, S.M. Moghimi, I.S. Vizirianakis, K. Avgoustakis, D.G.Fatouros and Z. Ahmad, New Platforms For Multi-Functional Ocular Lenses: Engineering Double Sided Functionalised Nano Coatings, Journal of Drug Targeting, 23 (2015) 305-310 
  53. Athina Angelopoulou, Efstathia Voulgari, Evmorfia K Diamanti, Dimitris Gournis, Konstantinos Avgoustakis, Graphene oxide stabilized by PLA-PEG copolymers for the controlled delivery of paclitaxel, E. J. Pharm. Biopharm., 93 (2015) 18-26. 
  54. P Siafaka, M Betsiou, A Tsolou, E Angelou, B Agianian, M Koffa, S Chaitidou, E Karavas, K Avgoustakis, D Bikiaris, Synthesis of folate-pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells, Journal of Materials Science: Materials in Medicine, 26 (2015) 1-14. 
  55. Ioannis S Vizirianakis, George A Mystridis, Konstantinos Avgoustakis, Dimitrios G Fatouros, Marios Spanakis, Enabling personalized cancer medicine decisions: The challenging pharmacological approach of PBPK models for nanomedicine and pharmacogenomics, Oncology reports, 35 (2016) 1891-1904. 
  56. Thalia Liargkova, Dimitra J. Hadjipavlou-Litina, Caterina Koukoulitsa, Efstathia Voulgari, and Constantinos Avgoustakis, Simple chalcones and bis-chalcones ethers as possible pleiotropic agents, Journal of Enzyme Inhibition and Medicinal Chemistry, 31 (2016) 302-313. 
  57. Yiannis Sarigiannis, Аrgiris Kolokithas-Ntoukas, Nicolas Beziere, Radek Zboril, Evangelia Papadimitriou, Konstantinos Avgoustakis, Margarita Lamprou, Zdenka Medrikova, Elias Rousalis, Vasilis Ntziachristos, Aristides Bakandritsos, Synthesis and evaluation of condensed magnetic nanocrystal clusters with in vivo multispectral optoacoustic tomography for tumour targeting, Biomaterials 91 (2016) 128-139. 
  58. Popescu, M.-T., Liontos, G., Avgeropoulos, A., Voulgari, E., Avgoustakis, K., Tsitsilianis, C., Injectable Hydrogel: Amplifying the pH Sensitivity of a Triblock Copolypeptide by Conjugating the N-Termini via Dynamic Covalent Bonding, ACS Applied Materials and Interfaces, 8 (2016) 17539-17548. 
  59. Voulgari Efstathia, Bakandritsos Aristides, Galtsidis Sotiris, Zoumpourlis Vassilis, Burke Benjamin P., Clemente Gonçalo S., Cawthorne Christopher, Archibald Stephen J., Tucek Jiri, Zboril Radek, Kantarelou Vasiliki, Karydas Andreas, Avgoustakis Konstantinos, Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers, Journal of Controlled Release 243 (2016) 342-356. 
  60. Koutsiouki, K., Angelopoulou, A.,Ioannou, E., Voulgari, E., Sergides, A., Magoulas, G.E., Bakandritsos, A., Avgoustakis, K. TAT Peptide-Conjugated Magnetic PLA-PEG Nanocapsules for the Targeted Delivery of Paclitaxel: In Vitro and Cell Studies, AAPS AAPS PharmSciTech., 18 (2017) 769-781. 
  61. Angelopoulou, A., Voulgari, E., Kolokithas-Ntoukas, A., Bakandritsos, A., Avgoustakis, K. Magnetic Nanoparticles for the Delivery of Dapagliflozin to Hypoxic Tumors: Physicochemical Characterization and Cell Studies, AAPS PharmSciTech., 2017, 1-13. 
  62. Peperidou, A., Pontiki, E., Hadjipavlou-Litina, D., Voulgari, E., Avgoustakis, K. Multifunctional cinnamic acid derivatives, Molecules, 22 (2017) 1247. 
  63. Athina Liaskoni, Athina Angelopoulou, Efstathia Voulgari, Maria-Teodora Popescu, Constantinos Tsitsilianis, Konstantinos Avgoustakis, Paclitaxel controlled delivery using a pH-responsive functional-AuNP/block-copolymer vesicular nanocarrier composite system, E. J. Pharm. Sci., (submitted). 

PRESENTATIONS (international conferences)

  1. Avgoustakis, K. and Georgakopoulos, P.P., “A study of possible improvements of USP XX dissolution test of hard gelatin capsules”. Proceedings of the 5th International Conference on Pharmaceutical Technology, APGI, Paris 1989, Vol. V, p. 460-468. 
  2. Z. Panagi, C. Sawas-Dimopoulou, K. Avgoustakis, D.S. Ithakissios. A quick labelling method for evaluating liposomes with regard their biodistribution properties. World Congress of Pharmacy 1994, Lisbon, Portugal, 4-9 September, 1994. Abstracts Book of the 54th International Congress of FIP:146 (P175) (1994). 
  3. Panagi, Z., Avgoustakis, K., Evangelatos, G. and Ithakissios, D.S., In vitro binding kinetics of serum proteins on selected liposomal types. Eur. J. Drug Metab. Pharmacokinet., Special Issue containing the abstracts of papers presented on 6th European Congress of Biopharmaceutics and Pharmacokinetics, Athens 1996. 
  4. Panagi, Z., Avgoustakis, K., Evangelatos, G. and Ithakissios, D.S., Carboxyfluorescein leakage kinetics from liposomes due to liposome-protein interaction in vitro. Eur. J. Drug Metab. Pharmacokinet., Special Issue containing the abstracts of papers presented on 6th European Congress of Biopharmaceutics and Pharmacokinetics, Athens 1996. 
  5. Panagi, Z., Avgoustakis, K., Evangelatos, G. and Ithakissios, D.S., Correlation of liposome-protein interaction in vitro with liposomes blood residence time in vivo. Eur. J. Drug Metab. Pharmacokinet., Special Issue containing the abstracts of papers presented on 6th European Congress of Biopharmaceutics and Pharmacokinetics, Athens 1996. 
  6. Z. Panagi, K. Avgoustakis, G. Evangelatos and D.S. Ithakissios. In vitro interaction of liposomes with serum proteins and its correlation with the in vivo blood residence time of liposomes. Third European Congress of Pharmaceutical Sciences, Edinburgh, 15-17 September, 1996. Eur. J. Pharm. Sci. Vol. 4 Suppl.:S43 (1996). 
  7. A. Beletsi, P. Klepetsanis, D. S. Ithakissios, S. Kounias, A. Stavropoulos and K. Avgoustakis. Optimized preparation of poly(lactide-co-glycolide)-poly(ethyleneglycol) nanoparticles loaded with cisplatin. Fourth European Congress of Pharmaceutical Sciences, Milan, 11-13 September, 1998. Eur. J. Pharm. Sci. Vol.6 Suppl.:S61 (1998). 
  8. A. Beletsi, P. Klepetsanis, D. S. Ithakissios, S. Kounias, A. Stavropoulos and K. Avgoustakis. Biodegradable stealth nanoparticles loaded with cisplatin. (Abstracts Book) International scientific meeting on “Biodegradable micro/nano-particles and their applications in Medicine, Patras, 27-28 September, 1999. 
  9. A. Beletsi, Z. Panagi, P. Klepetsanis, D. S. Ithakissios, L. Leondiadis, E. Livaniou, G. Evangelatos and K. Avgoustakis. PLGA-mPEG copolymers: Synthesis, characterization and application in the preparation of long circulating nanoparticles. (Abstracts Book) International scientific meeting on “Biodegradable micro/nano-particles and their applications in Medicine, Patras, 27-28 September, 1999. 
  10. Z. Panagi, , A. Beletsi, G. Evangelatos, P. Klepetsanis D.S. Ithakissios, and K. Avgoustakis. Biodistribution of PLGA-mPEG nanoparticles: effect of copolymer composition. 27th International Symposium on Controlled Release of Bioactive Materials, Paris, 7-13 July, 2000. 
  11.  V. Koutrafouri, L. Leondiadis, N. Ferderigos, K. Avgoustakis, E. Livaniou, G. P. Evangelatos and D.S. Ithakissios, Solid phase synthesis of thymosin beta-15 and investigation of its biological activity in the chorioallantoic membrane angiogenesis model. 26th European Peptide Symposium, Montpellier, France, September 10-15, 2000. 
  12. K. Avgoustakis, PLGAmPEG nanoparticles: preparation, characterization and application in controlled drug delivery. International Conference Particles 2002, Orlando, USA, 20-23- April 2002 (invited lecture). 
  13. N. Charalambopoulos, A. Karatzikou, K. Avgoustakis, C. Kontoyannis. Study of drug release properties of PLGA-mPEG nanoparticles using differential pulse polarography. 30th International Symposium on Controlled Release of Bioactive Materials, Glascow, 19-23 July, 2003. 
  14. G. Katsikogianni, K. Avgoustakis. PLGA-mPEG nanoparticles: drug encapsulation and release properties. 30th International Symposium on Controlled Release of Bioactive Materials, Glascow, 19-23 July, 2003. 
  15.  M. Effentakis, I. Pagoni, M. Vlachou, K. Avgoustakis. Effects of drug solubility on release and the dimensional changes utilizing image analysis. 30th International Symposium on Controlled Release of Bioactive Materials, Glascow, 19-23 July, 2003. 
  16. Georgios Blatsios, Achilleas Tzimas, Nikolaos Stivaktakis, Konstantinos Avgoustakis, Sotirios Gartaganis. Development of biodegradable microspheres for the transscleral controlled delivery of triamcinolone acetonide. Aegean Retina IX, 2005, Crete 1-3 July, 2005. 
  17. Chrysovalantis E. Griparis, Mariza Hatziapostolou, Evangelia Papadimitriou, Konstantinos Avgoustakis. PLGA-mPEG Nanoparticles of Cisplatin: Anticancer Activity against LNCaP Prostate Cancer Cells. 33rd Annual Meeting and Exposition of the Controlled Release Society, Vienna, Austria, 22-26 July, 2006. 
  18. George Mattheolabakis, George Lagoumintzis, Zoi Panagi, Evangelia Papadimitriou, Konstantinos Avgoustakis, “Transcutaneous immunization with antigen-loaded PLA nanospheres” 34th Annual Meeting and Exposition of the Controlled Release Society, Long Beach, USA, 7-11 July, 2007. 
  19. K. Avgoustakis. Targeted delivery of cisplatin using polymeric nanoparticles. EHRLICH II, 2nd World conference on magic bullets, Nurnberg, Germany, October 3-5, 2008 (invited presentation). 
  20. F. Amin, G. Mattheolabakis, K. Avgoustakis, P. Cox, and D.G Fatouros, “Solubilization of C60 fullerenes in amphiphilic molecules: Formulation development and molecular modeling studies” 35th Annual Meeting and Exposition of the Controlled Release Society, July 18-22, Copenhagen Denmark, 2009. 
  21. S. Kyriakopoulou, G. Mattheolabakis, S. Papadimitriou, E. Karavas, D. Bikiaris, and K. Avgoustakis, “Synthesis of PPSu-PEG copolymers and their application in the preparation of cisplatin-loaded nanoparticles for tumor targeting” 35th Annual Meeting and Exposition of the Controlled Release Society, July 18-22, Copenhagen Denmark, 2009. 
  22. A. Bakandritsos, G. Mattheolabakis, R. Zboril, N. Bouropoulos, D. Fatouros, and K. Avgoustakis, “Magnetically Modified Biodegradable Polymeric Nanospheres” 35th Annual Meeting and Exposition of the Controlled Release Society, July 18-22, Copenhagen Denmark, 2009. 
  23. F. Amin, G. Mattheolabakis, K. Avgoustakis, P. A. Cox, N. Bouropoulos, D.G Fatouros, “Solubilization of C60 Fullerenes in Amphiphilic Molecules: Formulation Development and Molecular Modeling Studies (P) ” CNANO 2009 International Conference on Carbon Nanostructured Materials, October 4-8, Santorini, Greece. 
  24. Alexandros A. Vassiliou, Sofia A. Papadimitriou, Dimitrios N. Bikiaris, Karavas E, Avgoustakis K “Biocompatibility and biodegradability of polyester-PEG triblock copolymers and their use as amphiphilic nanocarriers for drug delivery” 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology March 8–11, 2010, Malta. 
  25. Aristides Bakandritsos, George Mattheolabakis, Konstantinos Avgoustakis, Frank Winnefeld “Development of functional magnetic targeted carriers for cationic drugs”, 8th International conference on the scientific and clinical application of magnetic carriers, Warnemunde, Germany, 25-29 May, 2010.  
  26. E. Anagnostou, K. Avgoustakis, A. Papagiannopoulos, R. Zboril, S. Pispas, F. Winnefeld, “Specially Engineered Doxorubicin Nanocarriers”, 8th International Conference on Nanosciences and Nanotechnologies , 12-15 July 2011, Thessaloniki, Greece. 
  27. Konstantinos Avgoustakis, “Nanocarriers for the controlled delivery of bioactive agents” invited lecture, 1st workshop on Nanomaterials in Optoelectronic and Biomedical Applications, 17-18 February 2011, Nicosia, Cyprus. 
  28. Mingguang Li, Zoi Panagi, J. Shi, Konstantinos Avgoustakis, Joshua Reineke, PBPK Modeling and Property - Biodistribution Relationships of PLGAmPEG Nanoparticles, Controlled Release Society 37th Annual Meeting, Washington, D.C., 2011.  
  29. Aristides Bakandritsos, Eleni Anagnostou, Jiri Tucek, Radek Zboril, Konstantinos Avgoustakis, Frank Winnefeld, “Enhancing the performance of magnetic nanocarriers for doxorubicin”, NANOCON, October 23-25, 2012, Brno, Czech Republic,
  30. Theodora Panagiotopoulou, Athina Angelopoulou, Konstantinos Avgoustakis, Evmorfia K. Diamanti, Dimitrios Gournis, “PLA-PEG Modified Graphene Oxide as potential Anticancer Drug Delivery Vehicle”, oral presentation, 9th Hellenic polymer society conference, 29 November - 1 December 2012, Thessaloniki, Greece.  
  31. Spyroglou Foteini, Ioannou Eirini, Voulgari Efstathia, Bakandritsos Aristides, Kouzoudis Dimitris, Avgoustakis Konstantinos, “Magnetic PLA-PEG Nanocarriers of Paclitaxel”, 9th Hellenic polymer society conference, 29 November - 1 December 2012, Thessaloniki, Greece. 
  32. Voulgari Efstathia, Bakandritsos Aristides, Kouzoudis Dimitrios, Frank Winnefeld, Pavlos Klepetsanis , Avgoustakis Konstantinos, “Cisplatin-loaded magnetically targeted hybrid nanocarriers”, 9th Hellenic polymer society conference, 29 November - 1 December 2012, Thessaloniki, Greece. 
  33. Voulgari Efstathia, Bakandritsos Aristides, Frank Winnefeld, Avgoustakis Konstantinos, “Multifunctional magnetic nano-assemblies for the targeted delivery of cisplatin to tumors: In vitro evaluation and cell studies”, The European CLINAM and ETPN Summit, 6th European Conference for Clinical Nanomedicine and Targeted Medicine, June 23-26, 2013, Basel, Switzerland. 
  34. Konstantinos Avgoustakis, “Nanotechnology-based medicines”, oral presentation, The European CLINAM and ETPN Summit, 6th European Conference for Clinical Nanomedicine and Targeted Medicine, ETP Nanomedicine Brokerage and CLINAM Universities "Small Speeches", June 23-26, 2013, Basel, Switzerland. 
  35. M. Lamprou, Y. Sarigiannis, A. Bakandritsos, K. Avgoustakis, F. Winnefeld, S. Pispas, G. Moundrichas, R. Zboril, J. Tucek and E. Papadimitriou, “Effects of magnetic nanoparticles with poly(methacrylic acid)-graft-poly(ethylene glycol) on drug delivery to endothelial and cancer cells”, 5th International Meeting on Angiogenesis, Amsterdam, The Netherlands, March 12-14 2014. Angiogenesis 17 (3): 758, 2014. 
  36. N. Koutsospyrou, A. C. Sergides, E. Ioannou, A. Angelopoulou, A. Bakandritsos, K. Avgoustakis, “Multifunctional Nanocapsules of Ixabepilone: In vitro evaluation”, Nano MED International Conference on Nanotechnology in Medicine, February 26-28, 2014, London, UK. 
  37. A.C. Sergides, A. Bakandritsos, K. Avgoustakis, J. Tucek, R. Zboril, “Superparamagnetic PLA-PEG Nanoassemblies: Evaluation of synthetic Parameters Effects on Structure and Particle-Drug Interactions”, Nano MED International Conference on Nanotechnology in Medicine, February 26-28, 2014, London, UK.
  38. Y. Sarigiannis, A. Bakandritsos, M. Labropoulou, E. Papadimitriou, E. Voulgari, K. Avgoustakis, F. Winnefeld, S. Pispas, G. Moundrichas, R. Zboril, J. Tucek, “Surface Modification of Magnetic Nanoparticles with Poly(methacrylic acid)-graft-poly (ethylene glycol), and the Effects of the Molecular Structure on Drug Delivery”, Nano MED International Conference on Nanotechnology in Medicine, February 26-28, 2014, London, UK. 
  39. Koutsospyrou Nefeli, Andreas Sergides, Eirini Ioannou, Athina Angelopoulou, Bakandritsos Aristides, Avgoustakis Konstantinos, “Biodegradable magnetic nanocapsules of ixabepilone: in vitro study”, The European CLINAM and ETPN Summit, 7th European Conference for Clinical Nanomedicine and Targeted Medicine, June 23-25, 2014, Basel, Switzerland. 
  40. A. Angelopoulou, K. Avgoustakis, E. K. Diamanti, A. Kouloumpis, D. Gournis, “Nanographene oxide stabilized with biodegradable and biocompatible copolymers for the controlled delivery of anticancer drugs” 11th international Conference on Nanosciences and Nanotechnologies, July 8-11 2014, Thessaloniki, Greece (invited lecture).  
  41. Voulgari Efstathia, Bakandritsos Aristides, Winnefeld Frank, Galtsidis Sotiris, ZoumpourlisVassilis, Avgoustakis Konstantinos, Magnetic nano-assemblies with PEG graft copolymers for the targeted delivery of cisplatin to tumors, The European CLINAM and ETPN Summit, 7th European Conference for Clinical Nanomedicine and Targeted Medicine, June 28-July 1, 2015, Basel, Switzerland (oral presentation). 
  42. K. Avgoustakis, Multifunctional magnetic nanocarriers of anticancer drugs, 13th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology, July 24-25, 2017, Rome, Italy (invited oral presentation). 
  43. L. Papaioannou, A. Angelopoulou, M. Papadimitriou, P. Apostolou, I. Papasotiriou, K. Avgoustakis, Folic acid functionalized nanorods for the targeted paclitaxel delivery, 14th International Conference on Nanosciences &Nanotechnologies – NN17, 4-7 July 2017, Thessaloniki, Greece.  
  44. Aggeliki Liakopoulou, Konstantinos Avgoustakis, Sophia Hatziantoniou, Impact of Different Nanolipidic Carriers Containing Curcumin on Skin Occlusive Properties, International Liposome Society Conference, 16-18 September 2017, Athens, Greece