Evangelia Papadimitriou, Ph.D. Print

Evangelia Papadimitriou, Ph.D.
Professor of Molecular Pharmacology
Tel. : (+30) 2610 962336
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

For a short CV press here

EDUCATION

University: Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece; 1985-1989. Degree: B. Pharm
Graduate: Department of Medicine, School of Health Sciences, University of Patras, Patras, Greece; 1990-1994; Degree: Ph.D. in Pharmacology
Postdoctoral: School of Health Sciences, University of Patras, Patras, Greece; 1994-1995
                     School of Natural Sciences, University of Patras, Patras, Greece; 1996
                     School of Health Sciences, University of Patras, Patras, Greece; 1997-1998

ACADEMIC APPOINTMENTS

1991-1994: Research Assistant at the University of Wisconsin Medical School, Milwaukee Clinical Campus, Wisconsin, U.S.A
1995-1997: Assistant Professor of Pharmacology at the Department of Nursing, Faculty of Professions of Health and Providence, Higher technological and Educational Institute of Patras, Greece
1998-2003: Lecturer, 2003-2009: Assistant Professor, 2009-2015: Associate Professor and 2015-present: Professor of Molecular Pharmacology, Department of Pharmacy, University of Patras, Greece.
January 2015: Visiting Professor at the Academic Unit of Orthopaedic and Trauma Surgery, University of Leeds, UK.

CURRENT FOCUS OF RESEARCH

  • Angiogenesis and tumor growth in vitro and in vivo. Pharmacological studies on the mechanisms involved, and evaluation of new compounds or nanoparticles for their anti-angiogenic and anti-tumor activity.  
  • The biological actions of the heparin-binding growth factor pleiotrophin. Effects on endothelial cell functions, angiogenesis, tumor growth and metastasis, bone cell biology. Signaling and receptors identification. Structure-function studies and development of therapeutic applications.  
  • The role of receptor RPTPbeta/zeta in the cardiovascular and the skeletal system. Structure-function studies. .

TEACHING ACTIVITIES

Undergraduate:

  • Pharmacology Ι and ΙΙ
  • Molecular Pharmacology
  • Introduction to Pharmaceutical Sciences

Postgraduate:

  • Preclinical and Clinical Drug Evaluation
  • Molecular Targets of Drug Action
  • Precision Therapeutics

SELECTED PUBLICATIONS

  1. Mikelis C, Sfaelou E, Koutsioumpa M Kieffer N, Papadimitriou E. Integrin ανβ3 is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase β/ζ. FASEB J 23:1459-1469, 2009.
  2. Koutsioumpa M, Polytarchou C, Courty J, Zhang Y, Kieffer N, Mikelis C, Skandalis S, Hellman U, Iliopoulos D, Papadimitriou E. Interplay between alpha v beta 3 integrin and nucleolin regulates human endothelial and glioma cell migration. J Biol Chem 288:343-354, 2013.
  3. Koutsioumpa M, Poimenidi E, Pantazaka E, Theodoropoulou C, Skoura A, Megalïoikonomou V, Kieffer N, Courty J, Mizumoto S, Sugahara K, Papadimitriou E. Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor. Mol Cancer, 14:19, 2015.
  4. Papadimitriou E, Pantazaka E, Castana P, Tsalios T, Polyzos Α, Beis D. Pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta as regulators of angiogenesis and cancer. BBA Reviews on Cancer 1866:252-265, 2016.
  5. Lampropoulou E, Logoviti I, Koutsioumpa M, Hatziapostolou M, Polytarchou C, Skandalis SS, Hellman U, Fousteris M, Nikolaropoulos S, Choleva E, Skoura A, Megalooikonomou V, Papadimitriou E. Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration. Sci Rep 8:5893, 2018.
  6. Kastana P, Choleva E, Poimenidi E, Karamanos N, Sugahara K, Papadimitriou E. Insight into the role of chondroitin sulfate E in angiogenesis. FEBS J 2019; 286(15):2921-2936.
  7. Kastana P, Zahra FT, Ntenekou D, Katraki-Pavlou S, Beis D, Lionakis MS, Mikelis CM, Papadimitriou E. Matrigel Plug Assay for In Vivo Evaluation of Angiogenesis. Methods Mol Biol 1952:219-232, 2019.

OFFICE HOURS FOR COMMUNICATION WITH STUDENTS

Monday 12.00-14.00 and any other day, after appointment that can be arranged by email