Secretariat Time Programme
Daily
12:00 - 13:30

sfe

Laboratory of Molecular Pharmacology

RESEARCH ACTIVITY

The Major Research Focus of the Laboratory is Vascular Pharmacology

We specifically study the molecular mechanisms of physiological and pathological angiogenesis such as that seen in cancer, the pharmacological action of molecules modulating the function of vascular endothelial and smooth muscle cells, and the participation of the arterial wall in Inflammatory and Immune diseases

Laboratory Members

Faculty:
Evangelia Papadimitriou, Professor, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Stavros Topouzis, Associate Professor, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Post-Doctoral Researchers: 
Panagiotis Panopoulos, Ph.D.
Vassilis Kotsikoris, Ph.D.
Christina Malavaki, Ph.D.

The Laboratory is currently training 7 Graduate Students (6 Ph.D. and 1 M.Sc. degree candidates)

PhD Candidates:
Koutsioumpa Marina
Lamprou Margarita
Sotiria Tsirmoula
Poimenidi Evangelia
Bountouris Panagiotis
Bukar Umaru

MSc Candidate:
Antonia Asimakopoulou

BRIEF FACULTY PROFILES

Andreas Papapetropoulos, PhD, FAHA, FBPharmacolS
http://www.pharmacy.upatras.gr/index.php/en/personell/faculty-members/professors/20-papapetropoulos-andreas

Current projects
H2S : vascular actions and signalling, development and characterization of endogenous H2S synthesis inhibitors and H2S donors
Soluble guanylyl cyclase: molecular mechanisms of activation, therapeutic potential of sGC activators/stimulators

Recent representative publications

  • Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, Jeschked MG, Branskid L.K., Herndon D.N., Wang R. and Szabo C. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl. Acad Sci USA 106:21972-7, 2009
  • Morbidelli L., A. Pyriochou, S. Filippi, I. Vasileiadis, C. Roussos, Z. Zhou, H. Loutrari, J. Waltenberger, A. Stössel, A. Giannis, M. Ziche, A. Papapetropoulos. The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am J Physiol Regul Integr Comp Physiol.; 298:R824-32, 2010
  • A. Marazioti, M. Bucci M, C. Coletta, V. Vellecco, P. Baskaran, C. Szabo, G. Cirino, A.R.Marques, B. Guerreiro, A.M. Gonçalves, J.D. Seixas, A. Beuve, C.C. Romão, A. Papapetropoulos. Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules. Arterioscler Thromb Vasc Biol.31:2570-2576, 2011

Evangelia Papadimitriou, PhD
http://www.pharmacy.upatras.gr/index.php/en/personell/faculty-members/associate-professors/30-papadimitriou-evaggelia

Current projects
The biological actions of pleiotrophin, a new growth factor with high affinity to heparin
1. Signaling and receptors identification
2. Effects on EC functions, angiogenesis, tumor growth and metastasis, and bone cell biology

Recent representative publications

  • Hatziapostolou M, Polytarchou C, Katsoris P, Courty J, Papadimitriou E. Heparin affin regulatory peptide/pleiotrophin mediates fibroblast growth factor 2 stimulatory effects on human prostate cancer cells. J Biol Chem. 281:32217-26, 2006
  • Mikelis C., Sfaelou E., Koutsioumpa M, Kieffer N. and Papadimitriou E*. “Integrin αvβ3 is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase β/ζ”. FASEB J., 23: 1459-1469, 2009.
  • Mikelis C., Lamprou M., Koutsioumpa M., Koutsioubas A.G., Spyranti Z., Zompra A.A., Spiliopoulos N., Vradis A.A., Katsoris P., Spyroulias G.A., Cordopatis P., Courty J. and Papadimitriou E. “A peptide corresponding to the C-terminal region of pleiotrophin inhibits angiogenesis in vivo and in vitro”. J. Cell. Biochem. 112: 1532-1543, 2011.

Stavros Topouzis, PhD
http://www.pharmacy.upatras.gr/index.php/en/personell/faculty-members/assistant-professors/31-topouzis-stavros

Current projects
Regulation of Arterial Smooth Muscle and Endothelial Cell Phenotype:
- Function of the transcription factors SRF and Myocardin in H2S signaling and in angiogenesis
- Role for FSH-R in cancer blood vessel endothelial cells: impact on angiogenesis and function in solid tumor growth

Recent representative publications

  • Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA.(2004) Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol. 5:752-60.
  • JA Thomas, RA Deaton, NE Hastings, Y Shang, CW Moehle, U Eriksson, S Topouzis, BR Whamhoff, BR Blackman and GK Owens (2009) Platelet-Derived Growth Factor PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerotic-prone flow patterns, Am. J. Physiol. Heart Circ. Physiol.,296:H442-52.
  • Z Zhou, M von Wantoch Rekowski, C Coletta, C Szabo, M Bucci, G Cirino, S Topouzis, A Papapetropoulos and A Giannis (2012) Thioglycine and l-thiovaline: Biologically active H2S-donors., Bioorg Med Chem., 20:2675-8.

TEACHING ACTIVITIES OF THE LABORATORY

Undergraduate Courses:

  • Introduction to Pharmaceutical Sciences (32 Y 116)
  • Pharmacology I (32 Y 312)
  • Pharmacology II (32 Y 325)
  • Molecular Pharmacology (32 Y 426)
  • Toxicology (32 Y 421)

Graduate courses:

  • In vitro and in vivo systems used to study drug action (ΦΜ-A05)
  • Molecular targetrs of drug action (ΦΜ-A06)
  • Clinical Pharmacy (ΦΜ-Γ01)
  •  Toxicology-Drug interactions (ΦΜ-Γ03)
  •  Pharmacogenomics (ΦΜ-Γ05)
  •  Introduction to Pharmacology (ΦΜ-Δ08)

RESEARCH FUNDING (last 5 years)

  • Intramural: 3 grants
  • National: (General Secretariat of Research & Technology, Ministry of Education, Greek Society for Cardiology, Hellenic Society for the study of Bone Metabolism) 18 grants
  • European Union: 2 grants
  • International (in addition to EU): 4 grants