Secretariat Time Programme
12:00 - 13:30


Laboratory of Molecular Pharmacology


The Major Research Focus of the Laboratory is Vascular Pharmacology

We specifically study the molecular mechanisms of physiological and pathological angiogenesis such as that seen in cancer, the pharmacological action of molecules modulating the function of vascular endothelial and smooth muscle cells, and the participation of the arterial wall in Inflammatory and Immune diseases

Laboratory Members

Evangelia Papadimitriou, Professor, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Stavros Topouzis, Associate Professor, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Post-Doctoral Researchers: 
Panagiotis Panopoulos, Ph.D.
Vassilis Kotsikoris, Ph.D.
Christina Malavaki, Ph.D.

The Laboratory is currently training 7 Graduate Students (6 Ph.D. and 1 M.Sc. degree candidates)

PhD Candidates:
Koutsioumpa Marina
Lamprou Margarita
Sotiria Tsirmoula
Poimenidi Evangelia
Bountouris Panagiotis
Bukar Umaru

MSc Candidate:
Antonia Asimakopoulou


Andreas Papapetropoulos, PhD, FAHA, FBPharmacolS

Current projects
H2S : vascular actions and signalling, development and characterization of endogenous H2S synthesis inhibitors and H2S donors
Soluble guanylyl cyclase: molecular mechanisms of activation, therapeutic potential of sGC activators/stimulators

Recent representative publications

  • Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, Jeschked MG, Branskid L.K., Herndon D.N., Wang R. and Szabo C. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl. Acad Sci USA 106:21972-7, 2009
  • Morbidelli L., A. Pyriochou, S. Filippi, I. Vasileiadis, C. Roussos, Z. Zhou, H. Loutrari, J. Waltenberger, A. Stössel, A. Giannis, M. Ziche, A. Papapetropoulos. The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am J Physiol Regul Integr Comp Physiol.; 298:R824-32, 2010
  • A. Marazioti, M. Bucci M, C. Coletta, V. Vellecco, P. Baskaran, C. Szabo, G. Cirino, A.R.Marques, B. Guerreiro, A.M. Gonçalves, J.D. Seixas, A. Beuve, C.C. Romão, A. Papapetropoulos. Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules. Arterioscler Thromb Vasc Biol.31:2570-2576, 2011

Evangelia Papadimitriou, PhD

Current projects
The biological actions of pleiotrophin, a new growth factor with high affinity to heparin
1. Signaling and receptors identification
2. Effects on EC functions, angiogenesis, tumor growth and metastasis, and bone cell biology

Recent representative publications

  • Hatziapostolou M, Polytarchou C, Katsoris P, Courty J, Papadimitriou E. Heparin affin regulatory peptide/pleiotrophin mediates fibroblast growth factor 2 stimulatory effects on human prostate cancer cells. J Biol Chem. 281:32217-26, 2006
  • Mikelis C., Sfaelou E., Koutsioumpa M, Kieffer N. and Papadimitriou E*. “Integrin αvβ3 is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase β/ζ”. FASEB J., 23: 1459-1469, 2009.
  • Mikelis C., Lamprou M., Koutsioumpa M., Koutsioubas A.G., Spyranti Z., Zompra A.A., Spiliopoulos N., Vradis A.A., Katsoris P., Spyroulias G.A., Cordopatis P., Courty J. and Papadimitriou E. “A peptide corresponding to the C-terminal region of pleiotrophin inhibits angiogenesis in vivo and in vitro”. J. Cell. Biochem. 112: 1532-1543, 2011.

Stavros Topouzis, PhD


1985: Bachelor of Pharmacy, Aristotelian University of Thessaloniki, Greece
1986: Diplôme d'Etudes Approfondies (DEA) de Pharmacologie et Pharmacochimie, Université Louis Pasteur I, Strasbourg, France.
1989: Doctorat de Pharmacologie Moléculaire et Cellulaire, Université Louis Pasteur I, Strasbourg, France.


  • 1985-1990 Pharmacol. Moleculaire et Cellulaire, Faculte de Pharmacie, U. Louis Pasteur and Merrel-Dow Research Institute, Strasbourg, FRANCE
    Doctoral student / Researcher
    Biology of Nitric Oxide and Endothelin, Molecular Mechanisms of Arterial Contractility
  • 1990-1992 Dept. of Pharmacology/Toxicology, Medical College of GA, Augusta, Georgia USA
    Research Fellow and Graduate School Lecturer
    Endothelial and Vascular Smooth Muscle cell Biology, ACE activity in the vessel wall
  • 1992-1998 Dept. of Pathology, Baylor College of Medicine, Houston, Texas, USA
    Research Associate (Junior Faculty)
    Vascular Wall Morphogenesis, Smooth Muscle Cell Lineage Diversity, TGF-β biology
  • 1998-1999 Cell Biology/Discovery, MetaMorphix, Inc., Baltimore, Maryland USA
    Research Scientist
    Myostatin (GDF-8) biology, Skeletal Muscle growth and Glucose homeostasis
  • 1999-2006 Discovery Biology, ZymoGenetics Inc., Seattle, Washington, USA
    Senior Scientist / Project Leader
    Protein-based Therapeutics for Cancer, Vascular and Immune Diseases, and Regenerative Medicine
  • 2006- now Molecular Pharmacology, Dept. of Pharmacy Univeristy of Patras, Patras, GREECE
    Current position: Associate Professor of Pharmacology and Toxicology
    Research in Vascular, Inflammatory and Fibroproliferative diseases

FINANCIAL SUPPORT at the University of Patras

  1. Principal Investigator: K. Karatheodori Research Excellence Grant, "Modulation of the smooth muscle cell phenotype by alpha-1 adrenergic receptors", (30,000 €, U of Patras, 2009-12)
  2. Co-Investigator, Synergasia Consortium Grant (Academia-Industry cooperation) "Discovery of Plant-Derived Angiogenesis-Modulating Molecules" (Total Budget: 1,000,000 € - 380,000 € budgeted to the Lab. of Mol. Pharmacology, U of Patras - Coordinator: Lab. of Pharmacognosy, U of Athens, 2011-14)
  3. National Representative and MC Member, FP7 COST EU-Consortium grant "ENOG – European Network on Gasotransmitters: from basic science to therapeutic application", (Budget: 600,000 €, Coordinator: Lab of Mol. Pharmacology, U of Patras, 2011-15, Grant Holder: A. Pyriohou)
  4. Co-Investigator and Work Package Leader, REGPOT EU Project (started 01/2011) "ESTABLISHMENT OF A CENTRE OF EXCELLENCE FOR STRUCTURE-BASED DRUG TARGET CHARACTERIZATION: STRENGTHENING THE RESEARCH CAPACITY OF SOUTH-EASTERN EUROPE" ("SEE-DRUG"), Total Budget: 3,000,000 €, of which ~2,9000,000 € to the Dept. of Pharmacy (Coordinator: G.A. Spyroulias, Dept. of Pharmacy, U of Patras, 2011-15)
  5. Principal Investigator, Greece-Slovakia Cooperation "Study of the molecular mechanisms of action and functions of the novel endogenous gasotransmitter, hydrogen sulfide (H2S), in arterial cells (Total budget: 15,000 €, Coordinator: Lab. of Mol. Pharmacology, Dept. of Pharmacy, U of Patras, 2014-15)
  6. Co-Principal Investigator, THALIS Consortium "Hydrogen sulfide, a new endogenous regulator of angiogenesis: signaling, physiology/pathophysiology and development of pharmacological inhibitors" (Total budget: 500,00 €, Coordinator: Lab. of Mol. Pharmacology, Dept. of Pharmacy, U of Patras, 2011-15)
  8. Principal Investigator/Academic Advisor: "Reduced risk nicotine products: Comparative studies of their effects in respiratory and adipose tissue", (code ΕΔΒΜ34), ΟΠΣ 5006015, (Total Budget: 50,050 €, 2018-2019)
  9. Principal Investigator/Academic Advisor: "New functional activators of the soluble guanylate cyclase", (code ΕΔΒΜ34), ΟΠΣ 5005921, (Total Budget: 72,100 €, 2018-2019)


  • Makrynitsa GI et al., (2019) Therapeutic Targeting of the Soluble Guanylate Cyclase Curr Med Chem Jan 7. doi: 10.2174/0929867326666190108095851
  • Glynos et al., (2018) Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice Am J Physiol Lung Cell Mol Physiol, 315(5):L662-L672
  • Spathis AD et al., (2017) Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease Proc Natl Acad Sci USA 114(15):3999-4004
  • II Alexandropoulos et al., (2016) (1)H, (13)C, (15)N backbone and side-chain resonance assignment of Nostoc sp. C139A variant of the heme-nitric oxide/oxygen binding (H-NOX) domain Biomol NMR Assign, 10(2):395-400
  • B Umaru et al., (2015) KATP channel activation mediates angiogenic responses in vivo and in vitro J Pharmacol Exp Ther, 354:79-87
  • S-I Bibli et al., (2015) Role of cGMP in hydrogen sulfide signaling Nitric Oxide, 46:7-13
  • A Papapetropoulos et al., (2015) Extending the translational potential of targeting nitric oxide/cGMP-regulated pathways in the cardiovascular system Br J Pharmacol, 172(6):1397-414
  • C Glynos et al., (2015) Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation Am J Resp Cell Mol Biol, 52(6):762-71
  • SR Dillon et al., (2004) Interleukin 31, a cytokine produced by T cells, induces dermatitis in mice Nature Immunol, 5, 752-760
  • W Xu et al., (2001) A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist Proc. Natl. Acad. Sci. USA, 98, 9511-9116


  • United States Patent 7,172,757 February 6, 2007 Method of treating fibroproliferative disorders Inventors: Hart; Charles E. (Woodinville, WA); Topouzis; Stavros (Seattle, WA), Gilbertson; Debra G. (Seattle, WA) Assignee: ZymoGenetics, Inc. (Seattle, WA)
  • United States Patent 7,045,498 May 16, 2006 Soluble Zcytor11 cytokine receptors Inventors: Kindsvogel; Wayne R. (Seattle, WA); Topouzis; Stavros (Seattle, WA) Assignee: ZymoGenetics, Inc. (Seattle, WA)
  • United States Patent 6,827,938 December 7, 2004 Compositions and methods for improving kidney function Inventors: Hart; Charles E. (Woodinville, WA); Topouzis; Stavros (Seattle, WA) Assignee: ZymoGenetics, Inc. (Seattle, WA)
  • United States Patent 6,630,142 October 7, 2003 Method of treating fibroproliferative disorders Inventors: Hart; Charles E. (Woodinville, WA); Topouzis; Stavros (Seattle, WA), Gilbertson; Debra G. (Seattle, WA) Assignee: ZymoGenetics, Inc. (Seattle, WA)
  • United States Patent 6,368,597 April 9, 2002 Methods of treating diabetes Inventors: Strassmann; Gideon (Washington, DC), Liang; Li-fang (Elkridge, MD); Topouzis; Stavros (Elkridge, MD Assignee: MetaMorphix, Inc. (Baltimore, MD)

Listed as Inventor in >13 Published Patent Applications


Pharmacology of Vascular, Inflammatory and Fibroproliferative diseases

  • Past and present investigations address the molecular pathways operating in endothelial and smooth muscle cells and which are amenable to targeting by novel or optimized therapeutics.
  • These pathways control blood pressure and vascular resistance, inflammatory and thrombotic processes, solid tumor/wound angiogenesis, and are critically involved in the onset and progress of chronic cardiovascular and metabolic diseases (e.g. atherosclerosis, arterial calcification, restenosis).
  • At the cellular and molecular levels, past research has addressed a) critical aspects of phenotypic determination and functional control of vascular smooth muscle and endothelial cells, triggered by morphogenetic cues (e.g. TGF-β and PDGF) and transcriptional regulators (e,g, SRF, Myocardins, COUP-TF II), and b) modulation of the interaction of the blood vessel wall with circulating cells such as monocytes/macrophages, platelets and T-cells (e.g. IL-22Rα2, TFPI-2, CNP, IL-31).

Topics of current research are shown below