The Secretariat accepts students on weekdays from 12:00 - 13:30

sfe

Study Guide 2019-20

DPHA_A02 Modern methods in drug synthesis PDF Print

Instructors: V. Magafa, P. Magriotis, S. Nikolaropoulos, G. Pairas, M. Fousteris.

Co-ordinator: M. Fousteris

Content:

Allylic strain Α1,2 and Α1,3. Applications of allylic strain as controlling factor in stereoselective synthesis.
Asymmetric synthesis: Methods and applications in drug synthesis.
Asymmetric organocatalytic synthesis of saturated N-heterocyclic rings.
Chemistry of basic heterocycles incorporated in drugs.
Mechanisms of coupling reactions: Buchwald-Hartwig, Hiyama-Denmark, Kumada, Migita-Kosugi-Stille, Negishi, Suzuki-Miyaura, και Sonogashira.
Combinatorial Chemistry and Parallel Synthesis of bioactive compounds (Design and synthesis of compound libraries).
Synthesis of small bioactive molecules via multicomponent reactions.
Modern solid phase peptide synthesis (linkers, resins and general procedures).
Microwave-assisted solid-phase peptide synthesis.
Green peptide synthesis.
Enzyme-mediated peptide ligation.
Selected case studies in modern drug synthesis.