Education
1987: Ph.D. in Biochemistry, Aristotle University of Thessaloniki, Greece
1980: Diploma in Chemistry, University of Patras, Greece
Professional Appointments and Research Training
2019- Professor, Department of Pharmacy, School of Health Sciences University of Patras, GREECE
2015- Affiliated Investigator, Biomedical Research Foundation, Academy of Athens
2016- Visiting Professor, European University of Cyprus, Nicosia, CYPRUS
2014 Visiting Professor, Imagine Institute INSERM UMR 1163, University Hospital Institute,
Jan-June Université René Descartes Paris 5-Sorbonne Paris Cité, Paris, FRANCE
2003-2019 Associate Professor, Department of Pharmacy, University of Patras, GREECE
1993-2003 Assistant Professor, Department of Pharmacy, University of Patras, GREECE
1998 Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology/
Dana-Farber Cancer Institute, Cancer Biology (c/o Prof Arthur Pardee), Boston, MA, USA
1993-1995 Harvard Medical School, Department of Genetics and Microbiology and Dana-Farber
1996 (6 mo) Cancer Institute, Division of Cancer Genetics (c/o Prof Ruth Sager), Boston, MA, USA
1989-1993 Lecturer, Department of Pharmacy, University of Patras, GREECE
1988-1989 Invited Researcher, Institute of Physical & Chemical Research RIKEN, Saitama, JAPAN
1987-1988 Postdoctoral Fellow, NCSR "Demokritos" and Laboratory of Enzymatic Technology,
Technological University of Compiegne, Compiègne, FRANCE
1985 Graduate Fellow, Department of Biophysics, University of Osnabrück, GERMANY
1981-1985 Graduate Research Fellow, Institute of Biology, NCSR "Demokritos", GREECE
Hellenic Open University
2008-2015 Collaborating Faculty, Master's in Teaching Natural Sciences MSc
2005-2006 Collaborating Faculty, Studies in Natural Sciences
Prizes-Awards
2018 (Athens, GR)
Empirikion Research Prize
2014 (NY, USA)
Parkinson’s Disease Foundation’s International Research Grant Award
2013 (Toronto, CA)
"The E. K. Frey - E. Werle Promotion Prize" (2013)
Awarded by The E. K. Frey - E. Werle Foundation of the Henning L. Voigt Family (Munich, GER).
For important contributions to contemporary research in the kallikrein-kinin system and related fields.
1998 (Boston, USA)
Fulbright Senior Research Award
Harvard Medical School and the Dana-Farber Cancer Institute
“In vivo and in vitro assays for drug discovery-Functional evaluation of cystatin M as a tumor suppressor by the nude mouse assay. Development of an in vitro assay for screening anticancer drugs using the expression of the green fluorescent protein as a marker".
1998 (Nyborg, DK)
American Association for Cancer Research (AACR) Award
AACR Meeting on "Proteases and Protease Inhibitors in Cancer".
For the original identification and cloning of protease M (KLK6) gene and association to cancer.
1996 (Florida, USA)
American Association for Cancer Research (AACR) Award
AACR Special Conference on "Proteases and Protease Inhibitors in Cancer Research"
For the original identification and cloning of cystatin M gene and association to cancer.
1993 (Boston, USA)
Fulbright Senior Research Award
Harvard Medical School and the Dana-Farber Cancer Institute
“Identification and characterization of molecular markers for cancer Isolation of anti-peptide antibodies based on the identified markers”.
Teaching Activity
Undergraduate Program
- Cell Biology [PHA-A14-NEW]
- Pharmaceutical Biotechnology [PHA-C12-NEW]
Postgraduate Program “Drug Design and Development”
- Preclinical and Clinical Drug Evaluation [DPHA-4]
- Molecular Targets of Drug Action [DPHA_C01]
- Applied Biotechnology & Bioinformatics [DPHA_C02]
- Precision Therapeutics [DPHA_C03]
Research Activities
- Molecular mechanisms underlying cancer development, invasion and metastasis-Identification of genes/proteins for targeted pharmaceutical compounds and/or molecular diagnostics.
- Proteases and protease inhibitors (proteins/peptides, LMW/synthetic, aptamers).
- Kallikrein-related proteases (KLKs).
- Proteolytic pathways in normal physiology and disease states (skin overdesquamation and inflammation, α-synuclein processing, neoplastic progression).
- Animal models for preclinical testing of pharmaceutical compounds.
- Production and engineering of recombinant proteins of pharmacological interest.
Patents
- Sotiropoulou G, Pampalakis G, Bissyris E. (2018) “Theranostic inhibitors and activity-based probes for the KLK7 protease” Patent Application Nr: 2018010052, date: 16/11/2018.
- Hovnanian A, Sotiropoulou G, Pampalakis G, Furio L. (2014) "Methods and pharmaceutical compositions for the treatment of Netherton syndrome". Application Nr: EP14153629.2 (03 Feb 2014), Priority date: 2014-02-03; Filing date: 2015-02-02; Publication date: 2015-08-06, WO2015114144A1, ⇪
- Anisowicz A, Sager R, Sotiropoulou G. (1998) “Human protease M, a novel serine protease, and its cDNA sequence and diagnostic and therapeutic uses”. PCT Int. Patent, WO 98/11238, 1-92.
- Sotiropoulou G, Anisowicz A, Sager R. (1997) “Human cystatin M cDNA sequence, recombinant vector, gene regulation in tumor, and cancer diagnosis and therapy”. PCT Int. Patent, WO 97/14797, 1-67.
